THIOPENTAL SODIUM

Brand Name & Strength

Pentotex 0.5 g Injection

Reconstitution

Reconstitute with diluent

Further Dilution

IV infusion

Dilute with diluent to a final concentration of 0.2 – 0.4 %. Do not use WFI for these concentration, as hemolysis will occur

Diluent

NS, D5 Calculation Slow IV

IV infusion

WFI 10 – 20 ml - NS or D5 - 125 – 250 ml Concentration 25 – 50 mg/ml 2 – 4 mg/ml Concentration 2.5 % - 5 % 0.2 % - 0.4 %

Administration & Infusion rate

Slow IV Administer over 20 – 30 sec

IV infusion

Administer using infusion pump Rectal May be given rectally as solution for basal anaesthesia in a dose of up to 44 mg/kg; a dose of 30 mg/kg has been suggested for pre-anaesthetic sedation.

Storage & Stability

RT

(<25 oC)

Fridge

(2 – 8 oC)

After Reconstitution

Use immediately 24 hr

After dilution

Use immediately -

Remarks

Do not mix with solutions of succinylcholine, tubocurarine, or other drugs with acidic pH It is advisable to inject a small test dose of 25 – 75 mg (1 – 3 ml of a 2.5% solution) to assess tolerance or unusual sensitivity